Health Innovation Roundup

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Applied Pharmaceutical Innovation

48Hour Discovery partners with AdvanCell to advance radioligand cancer therapies

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We notice 48Hour Discovery has teamed up with AdvanCell to support the Australian company's work on radiotherapeutic alpha therapies to treat cancer. AdvanCell, which opened its first North American office in the Boston area in November, will leverage 48Hour Discovery's peptide discovery platform to develop the therapies, beginning with a focus on gastrointestinal cancer. "We see this program as an important validation of our discovery engine in the radioligand therapy space," said Rick Finnegan, 48Hour Discovery's Boston-based CEO, in a news release. "Importantly, this agreement is one of several partnerships we have entered into recently with companies developing radioligand therapies, and together they highlight the versatility of our platform across this rapidly growing modality."

Radioligand therapies are cancer drugs that pair a targeting molecule with a radioactive isotope so the medicine seeks out specific markers on tumour cells and delivers radiation right to them. 48Hour Discovery's peptide discovery platform, in its simplest terms, rapidly shortens the time it takes for drug development leads. It combines vast phage libraries, chemical modification, advanced screening methods, and more. The company, founded by Ratmir Derda, is a University of Alberta spinoff that has received funding from the CQDM Quantum Leap program and Glyconet, as well as Startup TNT and the Edmonton Edge Fund.

As its name implies, 48Hour is focused on drug discovery, but the company is part of a growing life sciences sector that also focuses on drug manufacturing. Applied Pharmaceutical Innovation expects to complete its Critical Medicines Production Centre this year, funded in part by the nearly $200-million Canadian Critical Drug Initiative that it runs in partnership with the U of A.

Health Innovation Roundup Sponsors

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Boehringer Ingelheim DrugBank Edmonton Global Health Innovation Hub Healthquest Action Lab

Headlines

Social innovation

  • RUNWITHIT Synthetics has launched INFLECTOR AI, an agent-based artificial intelligence platform that the company says uses 500 times less electricity than mainstream AI techniques for tasks such as synthesizing Canada's population data, while complying with global privacy regulations. "We've been stealth with INFLECTOR for a while, but given the realities of data centres and their consumption of critical resources, we thought it was time to put our hand up and say there is a different way," CEO Myrna Bittner said in a release. RWI's synthetic twins can make predictions on health outcomes among populations, among other things.
  • Teresa Spinelli of the Italian Centre Shop discussed stigma in the McCauley neighbourhood due to the concentration of services for people experiencing homelessness, mental illness, and addiction. Spinelli recently purchased The Piazza, a strip mall near the Italian Centre on 95 Street, which she said has helped fight the stigma. "Now you feel safe walking by that building at 8pm," she told CBC Edmonton's This is Edmonton podcast. "You don't have to worry about anyone attacking you."
  • Four Indigenous businesswomen have launched the Settle Down podcast. Shani Gwin of pipikwan pêhtâkwan and wâsikan kisewâtisiwin hosts the show alongside Felicia Dewar of miskamâsowin foods, Mallory Yawnghwe of Indigenous Box, and Vanessa Marshall of Jack59. The first episode is about how the hosts found their entrepreneurial fire. "There's crying, there's laughing, but what it really is about is lifting others up," Gwin told the St. Albert Gazette.
  • Areto Labs is hiring a lead product engineer. The company's services include eliminating hate speech and abuse within online communities.
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More health news

  • Educators and experts are calling for increased support for children's mental health in the wake of the Tumbler Ridge tragedy, noting that young people are experiencing loneliness and mental health challenges. Edmonton Public Schools superintendent Ron Thompson sent a note to families saying it's natural to feel distress in the wake of the mass shooting and that staff are willing to provide support to students, Postmedia reported. Meanwhile, the Lionheart Foundation told Global News about expanding its Edmonton operations to better support long-term mental health care for youth aged 12 to 25.
  • Edmonton Public Schools brought police officers back into six schools this month, after cancelling the program in September 2020 amid concerns about a "school-to-prison pipeline" for racialized students. The board voted to bring back the program in April 2024, citing increased school violence, including the April 2022 death of Karanveer Sahota. The redesigned program, developed with the Edmonton Police Service, features wraparound supports, mental health therapists, and a memorandum of understanding defining officers' preventative and educational roles.
  • It's time to stop ignoring the health of mid-life women, said Colleen Norris, a nursing professor at the University of Alberta. "Heart disease remains the leading cause of death for women in Canada," she wrote for Postmedia ahead of Wear Red Canada Day on Feb. 13. "Women are still more likely to be misdiagnosed, under-treated, and underrepresented in research. But the challenge is broader than cardiology. What continues to hold women's health back is a failure to recognize the central biological driver of lifelong health: ovarian function and estrogen."
  • The Grey Nuns Community Hospital's postpartum department became the first in the city to offer donated breast milk to patients, effective Feb. 13. Parents who need an alternative to formula or who cannot breastfeed can purchase 120 mL of breast milk for $19.
  • The Alberta Council of Women's Shelters is urging the province to keep independent oversight of domestic violence deaths or reinvest the funding into frontline services after Alberta's family violence death review committee ended its work in 2025. The council also called on the province to release the committee's latest report, expected this spring. The Ministry of Children and Family Services said resources will shift to "integrated, forward-looking prevention efforts" and frontline programs.
  • The City of Edmonton has activated its extreme weather response as temperatures are forecast to drop to -20°C or lower with wind chill for at least three consecutive days. The activation began on Feb. 16 and will be reassessed by Feb. 27. City facilities such as recreation centres and libraries are open for warming during regular hours, while additional overnight shelter shuttles are running along north and south routes. Al Rashid Mosque will not provide additional shelter spaces during this period in observance of Ramadan.
  • Nearly a month after Hospitals Minister Matt Jones announced triage liaison physicians would "immediately" start, the Alberta government will not confirm if any are on duty in busy Edmonton and Calgary emergency departments. This initiative was announced after the December death of Prashant Sreekumar at Edmonton's Grey Nuns Community Hospital. The Alberta Medical Association has not reached an agreement on TLP employment conditions. AMA section president and physician Warren Thirsk advised emergency department doctors against individual contracts due to liability concerns, calling the government's announcement "more of a communications exercise." David Climengaha followed up on TLP reporting with commentary on the matter.
  • More than 8,000 Albertans are sharing emergency room experiences as part of a Canadian Union of Public Employees campaign highlighting challenges in the province's healthcare system.
  • Friends of Medicare executive director Chris Gallaway urged federal lawmakers to act on health care privatization in Alberta, calling Bill 11 an "existential threat to public health care in Canada" that violates the Canada Health Act. Meanwhile, a report by the Montreal Economic Institute says Alberta's dual-practice model, which allows doctors to work in both public and private care, could help reduce the backlog for health services if implemented correctly.
  • University of Alberta law professor Timothy Caulfield warned about the impact of new U.S. vaccine policy changes, calling them "a complete mess" that could create confusion and hesitancy among Canadians. The policy slashes the number of vaccines recommended to children despite robust evidence of vaccine safety and effectiveness.

Happenings

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Sponsored

This roundup was sponsored by Applied Pharmaceutical Innovation.

API is one of Canada's largest not-for-profit life sciences commercialization organizations. We catalyze growth in the life sciences sector by addressing key challenges that hold companies and innovators back.

Applied Pharmaceutical Innovation

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